Scientific Area

Sebaceous glands


Collaborazione scientifica del prof. Marco Toscani e del dott. Pasquale Fino, Cattedra di Chirurgia Plastica, Ricostruttiva ed Estetica, Policlinico Umberto I – Università “Sapienza” di Roma.

The sebaceous glands are glands that secrete sebum, an oily, acidic substance with a pH of 3.5. They are connected laterally to the hair follicle. Sebaceous glands are found with a density of approximately 100/cm2 throughout all areas of the skin. In the human body, they are located across the entire surface of the skin, except for the palms of the hands and the soles of the feet. Sebaceous glands are also found in the external auditory meatus (ear canal) and on the eyelids, where they are long and flat. Here they are called tarsal or Meibomian glands.

Sebaceous glands are not distributed homogeneously over the body’s surface. There is a particularly elevated number (400-900/cm2) in the anogenital and in the so-called seborrheic regions (scalp, face, chest and back). In other regions of the body (such as in the forearm area), there are fewer glands. In some areas, like the corners and edges of the lips, the areola, the nipple, the anus, the vaginal libs and the glans (Tyson’s glands), sebaceous glands open directly onto the skin’s surface. They vary in size. They are larger in the pubic area, scrotum and nasal skin and are smaller at the level of the scalp. Like the nail bed and sweat glands, sebaceous glands are characterized by a dense capillary network. The sebaceous gland alveoli and the sweat gland glomeruli are enveloped by perialveolar nerve plexi or periglomerular cells, composed of fibers that lose the myelin sheath near glandular adenomas. In the numerous sweat glands are numerous andrenergic endings at the level of the myoepithelial cells of the glomeruli. Through these, nerve impulses may cause rapid secretions. Secretion cells are instead surrounded by cholinergic fibers. From a histological point of view, we can confirm that sebaceous glands are alveolar glands composed of branched tubes which give them their typical cluster shape. Apocrine sweat secretion is intermittent, while sebum secretion is continuous. The secretion mechanism first leads to an accumulation of sebum in the secretion cells, which increase continuously in volume and size, until they burst. Precisely for this reason not just sebum but also the remaining cells that produced it spill into the hair follicle. This necrosis is then compensated by the continuous production of new cell populations, coming from groups of undifferentiated cells that retained the ability to divide repeatedly. Once formed, the new cells detach from the tube walls and begin to produce sebum, migrating next to the follicle where they dismantle, leaving their contents. Sebaceous gland function is influenced by several factors. Sebaceous gland secretion is controlled by steroid hormones circulating or produced locally by the pilosebaceous follicle, starting from building blocks coming from the gonads or the adrenal cortex (the most active of these is androstanediol). The sebaceous glands produce abundant sebum during fetal development (a fetus’s vernix caseosa). They are active during the first months of life. They then pass to a phase of relative dormancy until 9-10 years of age, and reactivate during adrenarche. They then return to full activity during puberty due to small dermatological phenomena, the epitome of which is the phenomenon of common teenage acne. When there are no particular scalp problems, the production of sebum undergoes an abrupt reduction in women during menopause, while in men it diminishes only very slowly after 60 – 70 years of age. Sebum secretion is also influenced by genetic factors. Greasy skin is often a common problem among members of the same family. The most important factor regulating sebum secretion is the concentration of androgenic hormones, typical of men but also present in small quantities in women. In particular, at the level of the sebaceous glands, we find an enzyme called 5-alpha reductase, which converts delta 4-androstenedione into dihydrotestosterone, a metabolite with the ability to notably increase sebum secretion. Sebum also goes into the composition of hydrolipidic film. This oily mass also contributes to one’s characteristic and personal body odor, to the extent that lipid composition differs slightly from individual to individual. Sebaceous gland cells are enzyme rich and contain glycogen. The sebum that comes out and accumulates on the skin is composed as follows: triglycerides 30-42%, wax 20-25%, free fatty acids 15-25%, squalene 9-12%, branched hydrocarbons 4-8%, esterified cholesterol 2-3%, free cholesterol 1-1.5% and other substances (such as monoglycerides, glycerol, etc.) 3-5%. After being produced, the sebum reaches the surface through gland orifices, hair follicles and wedges into spaces of the disjointed corneum layer, also layering itself onto hair. Thus, it mixes with lipids from the skin and with the aqueous component of perspiration and sweat, forming a thin superficial emulsion called cutaneous hydrolipidic film. Sebum has two main functions. The first is to contribute through sweat to the formation of the hydrolipidic film, an emulsion of water/oil that protects the skin from chemical (detergents, solvents) and bacterial aggressors. The second is to lubricate and waterproof the external surface of the hair as it grows. The sebaceous gland duct opens into the upper part of the follicle in order to lubricate the hair before it appears on the skin’s surface. In normal conditions, total sebum production on the scalp is 650 – 700 mg every 24 hours. After removal via the use of soap, the hydrolipidic film (water/oil emulsion formed by a mixture of sebum with water from sweat) reforms in a relatively short amount of time (3 – 6 hours) but the sebaceous gland does not seem to be able to increase its activity compared to the base values for frequent washes. Sebum is unable to remove itself on its own from the hair shaft. The fact that hair can rapidly “get greasy” again after a wash is due to the reduction of superficial tension between the “keratin shingles” of the cuticle, associated with the continuous rubbing between hair. The speed of sebum migration increases if hair is continuously touched by hands or brushed. Moreover, in individuals with hair that gets particularly greasy in a short amount of time, sebum is more fluid and therefore has a higher migratory capacity. In individuals with seborrhea, the abundance of sebum causes aesthetic issues due to the easy adhesion of environmental dust, keratin residue and waste substances carried by sweat. All too often these problems are accentuated by the effects of applying cosmetics to the hair.

Scalp itchiness

Scalp itchiness of varying intensity is a sensation perceived by many people of both sexes.
Itchiness is a scalp problem that leads those afflicted to scratch their skin and is often associated with pain. Many causes of this illness are recognized, which shouldn’t be underestimated as it may cause hair loss or thinning.

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Seborrheic alopecia (seborrheic hair loss)

Seborrheic hair loss is a form of premature hair loss that generally afflicts men in their youth (onset between 20 and 30 years of age), mainly affecting the frontal region and the crown. The cause, as the name of the condition suggests, is related to an excess production of sebum that provokes or accelerates hair loss.

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Grey hair

In the trichological field, with the passing of age hair whitening is seen to follow the greying process of the hair on the scalp (called grey hair). Hair becomes grey (white) following a natural biological aging process of the melanocytes, which are the cells tasked with coloring hair.
In the majority of people, the first grey hairs appear around 35/40 years of age in women and around 30/35 in men.

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Androgenetic alopecia (pattern hair loss) or baldness

Androgenetic alopecia is the most common type of hair loss and affects the majority of white men, with varying degrees of seriousness. It is less frequent in other ethnic groups. Often it can be associated with a family history of baldness, but the absence of other affected family members does not exclude the diagnosis. The condition is characterized by progressive hair loss in the crown area, the front hairline and the temporal area.

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Damaged hair

Changes in the hair shaft lead to deterioration with the appearance of ruined or damaged hair.
In healthy hair, the cuticle is whole, with overlapping shingles. Hair with whole ends appears shiny, elastic and brushes easily.

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Hair loss: manifestation, causes and prevention

A shedding of hair is considered physiologically normal when hair loss is limited to around one hundred hairs per day. During an individual’s life hair grows, falls out and regrows around twenty times. Each cycle, especially for females, may last up to six years and if hair loss is found within this time frame, it is considered absolutely physiological.

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