Scientific collaboration between Professor Marco Toscani and Dr. Pasquale Fino, Chair of Plastic, Reconstructive and Aesthetic Surgery, Umberto I Health Center – “Sapienza” University of Rome.
The acronym PRPHT stands for “Platelet Rich Plasma Hair Therapy”. It is a therapeutic medical technique that falls within the field of “regenerative medicine”; it is based on the principle that stem cells, which have been demonstrated to be present in the hair bulb, are equipped with growth factor receptors.
The platelet concentrate, rich in growth factors, is injected into the scalp with very thin needles and then a massage is performed to facilitate its distribution. The patient may return to his/her normal life after just a few hours. Hair growth starts to show 2-4 months after the first session, and reaches its peak after 6 months. Then, some call-back sessions are generally performed 3-4 times per year, according to the severity of the case.
This clinical protocol is innovative in the field of hair loss treatments, while PRP has already been used for several years in orthopaedic, oral & maxillofacial and eye surgery, in the treatment of chronic ulcers, in the field of cosmetic surgery for biorevitalization and skin rejuvenation and to stimulate adipose stem cells in autologous lipofilling.
We can therefore exploit the very complicated system of growth factors capable of healing injuries in many organs of the body. Each organ is controlled by specific growth factors, and those of the skin are IGF-1, FGH, and VEGH.
Platelets are bodily cells that circulate in the blood and are active in the blood coagulation process for wounds and bleeding. They are actually among the first cells to trigger the repair and regrowth process of damaged cells; as soon as tissue is damaged, the platelets are “activated” by various natural chemical factors (inflammatory processes, cytokines, macrophages, etc.) and stimulate the cells to “repair themselves”.
Either after hair transplants or following the injection of PRP directly into the scalp suffering from hair loss, it is possible to stimulate the bulb with an autologous substance, rich in growth factors. Since PRP is a natural substance taken from the patient, there are no side effects such as possible allergies or intolerances. It is non-toxic and stimulates biorepair and regenerative processes. It stimulates angiogenesis and tissue revascularization. It stimulates the proliferation of mesenchymal cells and, in particular, adult mesenchymal stem cells. It stimulates the formation of collagen. PRP is therefore a source of Growth Factors that derive from the platelet granules of the patient.
PRP is obtained by concentrating the autologous platelets of the patient. A small quantity of blood is drawn (usually 20cc) from the patient, by collecting it in sterile single-use suction tubes with anticoagulant. The tubes are centrifuged for a few minutes, at a specifically scheduled number of turns.
The blood does not come into contact with the environment or with the operator, let alone with the instrument. At the end of the centrifugation, the samples are analysed in two phases: the lower sediment part features red and white blood cells. The upper part features plasma and platelets with growth factors. By using a special pipette, the PRP is suctioned and a chemical activator is added to degranulate the platelets, facilitating the outflow of growth factors. The prepared PRP may then be injected into the scalp by using a sterile syringe.
The operations must be consecutive, given that the platelets have a short lifespan. The blood must be drawn from the individual who is to be treated. The preparation, which lasts around 45 minutes, is carried out by specialized clinical personnel or hematologists. Thus, no risks are present in this treatment. The centrifugation does not alter the blood cells and is used solely to separate them. If the entire procedure carried out by qualified personnel is conducted in a designated environment, there is no risk of contamination.
As far as results in hair loss treatments are concerned, the growth factors stimulate the bulb cells (of the dermal papilla, matrix and melanocytes) to keep the anagen phase active, produce the hair shaft, reduce inflammatory processes in the skin and reduce cellular death. Moreover, the extremely high concentration of natural growth factors is able to stimulate stem cells in the remaining bulbs to once again generate a hair bulb. Thus, in the case of pattern hair loss, this procedure can lead to the regrowth of a number of hairs (obviously not quantifiable beforehand), especially in the early stages of the illness (in particular from stages I to IV of the Hamilton scale and in stages I to II of the Ludwig scale).
According to scientific literature, significant growth is seen in 60-70% of cases. On average, 2-4 sessions are performed over the course of 3 months; in alopecia areata (spot baldness), this may well be the most important treatment technique in terms of hair regrowth percentages in active patches. In scarring hair loss, it may have a significant effect on inflammation control and for decreasing the progression of active hair bulb death, especially in early forms. If residual hair follicle stem cells exist in the dermis, they may also be stimulated.
PRP therapy can be considered one of the most advanced and effective therapy techniques in the trichological field. Success depends, however, on the type of illness, on various concurrent situations and on the presence or lack of stem cells that may be activated. The most advanced theories now tend to use a treatment with PRP before, during or after the micro-autotransplant operation, in order to obtain:
– faster implantation of transplanted bulbs
– an increase in the bulb implantation percentage
– growth stimulation of silent bulbs
– faster healing of the scalp treated with the hair transplant.
Greasy hair appears dirty, greasy, oily, shiny and often has an unpleasant odor.
Individuals who have greasy hair often also have other areas of the skin (nose, forehead, chin) that are quite greasy (called “seborrheic” skin).
The hair on our bodies has a particular structure and is divided into thin and thick hair. Thin hair, also called lanugo or vellus, is located on all skin surfaces except for the palms of the hands and the soles of the feet. Thick hair, also called terminal hair, is dark and located only in some areas such as the scalp, the armpits, the pubic area, the beard area in the case of men, etc…
The term Telogen Effluvium was introduced for the first time by Kligman (*) in 1961 to introduce an acute hair loss of benign origin that follows an intense and short period of stress of different types. Subsequently, Rebora (**) introduced the concept of chronic Telogen Effluvium.
Scalp pain and irritation (or trichodynia) are pathological conditions that affect both women (in a greater percentage) and men (in a lower percentage). The pain felt on the scalp, spontaneous or caused by treatment, and in particular around the roots of the hair, may be more or less intense, alternating at times between periods of disappearance, associated with burning, tingling or itching.
Female hair loss is a common form of non-scarring hair loss, characterized by the progressive loss of hair in the forehead and crown regions, resulting in visible thinning. Unlike male hair loss, female hair loss in the affected areas is usually incomplete and the occipital area is generally spared.
Dry skin or asteatosis is a scalp condition deriving from a lipid deficiency.
It is often associated with a situation of exacerbated dehydration. We can identify both internal and external causes for this anomaly.
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